Can winter depression be prevented by Ginkgo biloba extract? A placebo-controlled trial

Author(s): Foreland, A. R., Magnusson, A.

Journal/Book: Acta Psychiat Scand. 1999; 100: 35 Norre Sogade, PO Box 2148, Dk-1016 Copenhagen, Denmark. Munksgaard Int Publ Ltd. 62-66.

Abstract: Objective: The aim was to test the hypothesis that the Ginkgo biloba extract PN246, in tablet form (brand name Bio-Biloba), may prevent the symptoms of winter depression (WD) in patients with seasonal affective disorder (SAD). Method: A total of 27 SAD patients were randomized to receive double-blind placebo or Bio-Biloba for 10 weeks or until they developed symptoms of WD, starting in a symptom-free phase about 1 month before expected WD symptoms. An extended Montgomery-Asberg Depression Rating Scale was completed before and immediately after termination of medication. The patients also self-rated some key symptoms on a visual analogue scale every 2 weeks during the trial. Results: There were no significant differences between the treatment groups in the number of patients who developed treatment-requiring WD, or in the development of single key symptoms during the trial. Conclusion: We did not find that Ginkgo biloba was able to prevent the development of the symptoms of winter depression.

Note: Article Lingaerde O, Aker Sykehus, Div Psykiat, Dept Res & Educ, Avd 6, Sognsvannsvn 21, N-0320 Oslo, NORWAY

Keyword(s): seasonal affective disorder; Ginkgo biloba; prophylaxis; controlled trial; SEASONAL AFFECTIVE-DISORDER; CEREBRAL BLOOD-FLOW; LIGHT TREATMENT; THERAPY

Zurück | Weiter