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November 2021

Impaired sensory processing in male patients with schizophrenia: a magnetoencephalographic study of auditory mismatch detection

Author(s): Rosburg, T., Meier, T., Volz, H. P., Nowak, H., Sauer, H.

Journal/Book: Schizophr Res. 1999; 35: PO Box 211, 1000 AE Amsterdam, Netherlands. Elsevier Science Bv. 121-129.

Abstract: The generation of mismatch negativity (MMN) as a component of auditory evoked event-related brain potentials has been reported previously to be severely disturbed in patients with schizophrenia. In the present study, we extended these findings to magnetoencephalography and investigated the neuromagnetic mismatch field (MMNm) in 15 male schizophrenic inpatients as compared to 16 healthy male volunteers. A standard tone of 1000 Hz and three different types of mismatch (1050-Hz tone, 5000-Hz tone, tone omission) were employed within the same paradigm, each mismatch occurring with a 10% pseudorandom probability. After correction for eye artifacts, the mean global field power of the mismatch reaction was calculated. Mismatch generation in patients with schizophrenia proved to be significantly impaired for all three conditions. This result confirms the theory of impaired auditory information processing in patients with schizophrenia at the level of the primary auditory cortex. Deficient generation of MMNm probably represents an impaired generation and/or faster decay of the sensory memory trace on the basis of disturbed sensory processing in male patients with schizophrenia.

Note: Article Kreitschmann-Andermahr I, Univ Technol, Dept Neurosurg, Rhein Westfal TH Aachen, Pauwelsstr 30, D-52074 Aachen, GERMANY

Keyword(s): mismatch negativity; schizophrenia; magnetoencephalography; auditory information processing; EVENT-RELATED POTENTIALS; EVOKED MAGNETIC-FIELDS; LEFT-HEMISPHERE; EYE-MOVEMENTS; NEGATIVITY; ABNORMALITIES; MEMORY; DYSFUNCTION; GENERATORS

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