Environmental lighting has a selective influence on ethanol intake in rats

Author(s): Amir, S., Amit, Z.

Journal/Book: Physiol Behav. 1999; 66: the Boulevard Langford Lane, Kidlington, Oxford Ox5 1GB, England. Pergamon-Elsevier Science Ltd. 323-328.

Abstract: The effect of lighting condition on levels of absolute ethanol intake were systematically examined in the present study. Wistar rats were exposed to one of three lighting conditions: constant light, constant dark, and a standard 12/12 light/dark cycle. The animals were acclimatized to lighting conditions for 2 weeks prior to ethanol (EtOH) acquisition with water and food available ad lib. EtOH was then presented in increasing concentrations from 2% (v/v; 95% with tap water) to 10% on alternate days in free choice with water. Immediately following the acquisition phase, a maintenance period was initiated that began with everyday presentations of 10% EtOH solution in free choice with water. After 10 days, lighting conditions for the constant light and dark groups were switched to normal lighting (12/12 light/dark). EtOH and water intake were recorded for an additional 10 days. Rats exposed to constant light during EtOH acquisition and maintenance consumed less EtOH during the maintenance period than rats exposed to normal lighting conditions. When lighting conditions were switched to a normal cycle, water consumption increased significantly but EtOH intake did not change. Rats living in constant dark during EtOH acquisition and maintenance consumed less EtOH during the acquisition period when compared with rats living in normal lighting conditions. Unlike animals trained under constant lighting, switching to normal lighting conditions had no effect on EtOH or water intake. There were no differences in water consumption levels among the groups during acquisition and maintenance, suggesting a specificity of the effects of lighting condition on EtOH intake. The present study, therefore, has attempted to show that an environmental variable such as lighting may exert a selective influence on EtOH self-selection in rats.

Note: Article Goodwin FLW, Concordia Univ, Ctr Studies Behav Neurobiol, 1455 Maisonneuve Blvd O, Psychol H-1013, Montreal, PQ H3G 1M8, CANADA

Keyword(s): ethanol; lighting; circadian; constant light; constant dark; rats; CONSTANT LIGHT; RHYTHMS; PHOTOPERIOD; HAMSTERS; DISEASE

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