Inhibitory effect of some triterpenes from cacti on 32Pi-incorporation into phospholipids of HeLa cells promoted by 12-0-tetradecanoylphorbol-13-acetate

Author(s): Yang, Y., Koyama, K., Takahashi, K., Nishino, H.

Abstract: Seventeen triterpenes isolated from cacti and the 10 derivatives were examined for the inhibition of tumor promoter-induced effects in vitro, such as stimulation of 32Pi-incorporation into phospholipids of cultured cells. Betulinic acid (1), cochalic acid (15), crythrodiol (16), oleanolic acid (21) and queretaroic acid (24) inhibited 12-0-tetradecanoylphorbol-13-acetate (TPA) stimualted 32Pi-incorporation into phospholipids of the cultured cells.

Keyword(s): anti-tumor promoter

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