Sedative actions of Temstroemia sylvatica in the male rat

Author(s): Contreras, C., Tellez-Alcantara, P., Rodriguez, F.

Abstract: Ternstroemia sylvatica is a plant reputed popularly to possess a anxiolytic properties but has not yet been systematically tested for such activity. The behavioral actions of T sylvatica were examined using the open field test, the elevated plus-maze test, and the forced swim test in male rats. T sylvatica (7.1 mg/kg and 14.2 mg/kg, I.P.) reduced ambulatory behavior in the open field test and cancelled the anti-immobility actions produced by desipramine (32 mg/kg,I.P.) in the forced swim test, as did diazepam. In the elevated plus-maze test, T sylvatica (7.1 mg/kg, I.P.) failed to show anxiolytic actions. lt is concluded that Ternstroemia sylvatica produces sedative effects rather than the attributed anxiolytic actions.

Keyword(s): Anxiolytic

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