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October 2021

Pain. 1998 May; 76(1-2): 3-8.

Cannabis for migraine treatment: the once and future prescription? An historical and scientific review.

Russo E.

Department of Neurology, Western Montana Clinic, Missoula 58907-7609, USA. [email protected]

Cannabis, or Marijuana, has been used for centuries for both symptomatic and prophylactic treatment of migraine. It was highly esteemed as a headache remedy by the most prominent physicians of the age between 1874 and 1942, remaining part of the Western pharmacopoeia for this indication even into the mid-twentieth century. Current ethnobotanical and anecdotal references continue to refer to its efficacy for this malady, while biochemical studies of THC and anandamide have provided a scientific basis for such treatment. The author believes that controlled clinical trials of Cannabis in acute migraine treatment are warranted.


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