Planta Med. 1998 Mar; 64(2): 192-3.

Alkamides from Phyllanthus fraternus.

Sittie AA, Lemmich E, Olsen CE, Hviid L, BrÃ¸gger Christensen S.

Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have been isolated from Phyllanthus fraternus, a plant used in Ghanaian traditional medicine to treat malaria. The compounds possess an alpha, beta, gamma, delta-unsaturated conjugated amide, a feature believed to enhance antiplasmodial activity. By means of an in vitro assay the two alkamides have been shown to possess moderate antiplasmodial activity.