Zhonghua Kou Qiang Yi Xue Za Zhi. 1998 Jan; 33(1): 50-2.
[The orthogonal design study on tumor-inhibition and cancer-block role of Chinese medicinal 1023 co.]
Xiamen Stomatologic Hospital, Xiamen 361003.
OBJECTIVE: To study the effect of Chinese herb medicine on the inhibition of tumor formation and block of malignant transformation. METHODS: The Chinese medicine 1023 co. was given by intubation feeding started simultaneously with the painting of 0.5% DMBA on the hamster's cheek mucosa. RESULTS: The tumor formation in 1023 co. group was delayed for 12 days comparing with the control group and the incidence of dysplasia and cancer in 1023 co. group was lower significantly than that of the control group (P < 0.01). CONCLUSION: The 1023 co. is effective in inhibiting tumor formation and blocking cancerous transformation. By orthogonal design we find the proper prescription is A2 B2 C2 D1.