Zhongguo Zhong Yao Za Zhi. 1998 Jun; 23(6): 344-7, 382-3.

[Effects of processing on toxicity and pharmacological action of flos Genkwa]

Zhao Y, Yuan S, Li A, Zhang B, Wang Z.

Institute of Traditional Medicine, Guangxi College of TCM, Nanning 530001.

Daphne genkwa can not be taken unless the toxicity is removed. The study on the effect of processing on the toxicity and pharmacological action of Flos Genkwa has shown that the toxicity of vinegar-processed Flos Genkwa is lower than that of the rude drug, but the pharmacological action is better. Both genkwanin and its vinegar-processed imitation have antitussive and expectorant actions without marked difference in efficacy. Both yuanhuacine and its vinegar-processed imitation could cause contraction of the extracorporeal womb and the intestinal canal, and the efficacy is almost similar in the concentration of 1:10(-5)-10(-6). The gestational womb was observed more sensitive than the normal one.