Zhongguo Zhong Yao Za Zhi. 1998 Oct; 23(10): 630-2, inside back cover.

[Influence of huanglian used in combination with huangqin and gancao on the erythrocytic osmotic fragilitas of experimental glucose-6-phosphate dehydrogenase deficiency in rats]

Lin N, Gao X, Li J, Zhu J.

Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700.

OBJECTIVE: To study the influence of common combination of Huanglian(Coptis chinensis) on the erythrocytic osmotic fragilitas of glucose-6-phosphate dehydrogenase(G6PD) deficiency in rats. METHOD: Various decoctions with Huanglian mixed with Huangqin (Scutellaria baicalensis) and Gancao(Glycyrrhiza uralensis) were orally administered to the G6PD deficiency rat model, and the erythrocytic osmotic fragilitas was measured. RESULT: The erythrocytic osmotic fragilitas after the combined use of Huanglian appears lower than (or equal to) that of Huanglian used alone(or even not used). The fragilitas lowers depending largely on the medicine in combination, dosage and proportion. CONCLUSION: Proper use of Huanglian in combination with Huangqin and Gancao is of some significance in lowering the erythrocytic osmotic fragilitas of G6PD deficiency in rats.