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Zhongguo Zhong Xi Yi Jie He Za Zhi. 1998 Feb; 18(2): 88-91.

[Clinical study on tripterygium wilfordii complex ester tablet in treating rheumatoid arthritis]

Du X, Zhang H, Fu X.

Affiliated Hospital of Shandong Traditional Chinese Medical University, Jinan 250011.

OBJECTIVE: To observe the curative effect, toxic and side effect of Tripterygium Wilfordii Complex Ester Tablet (TWT, a preparation of Folium Tripterygium wilfordii) in treating rheumatoid arthritis. METHODS: Two hundred and seventy seven patients were observed with prospective, multicentric and random double-blind control method. One hundred and forty cases of TWT group were treated with TWT 2 tablets each time, 3 times a day orally, and the other 137 cases treated with Tripterygium Wilfordii Polycoside Tablet (TPT, a preparation of Radix Tripterygium Wilfordii) 2 tablets each time were taken as control, 3 times a day orally. The therapeutic course for both groups was 6 weeks. RESULTS: The markedly controlled rate of the TWT group was 26.71% and the total effective rate was 86.43%, while those in the control group were 26.28% and 83.94% respectively, the difference between the two groups was insignificant (P > 0.05). The occurrence of side-effect in the two groups was 20.00% and 23.35% respectively, also showed no significant difference (P > 0.05). CONCLUSION: The Folium Tripterygium Wilfordii preparation is similar in efficacy and security to the Radix Tripterygium Wilfordii preparation.

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