Intensive lifestyle changes for reversal of coronary heart disease

Author(s): Ornish, D., Scherwitz, L. W. , Billing, J. H. , Gould, K. L. , Merritt, T. A. , Sparler, S. , Armstrong, W. T. , Ports, T. A. , Kirkeeide, R. L. , Hogeboom, C. , Brand, R. J.

Journal/Book: JAMA. 1998; 280(23): 2001-2007.

Abstract: Context.-The Lifestyle Heart Trial demonstrated that intensive lifestyle changes may lead to regression of coronary atherosclerosis after 1 year. Objectives.-To determine the feasibility of patients to sustain intensive lifestyle changes for a total of 5 years and the effects of these lifestyle changes (without lipid-lowering drugs) on coronary heart disease. Design.-Randomized controlled trial conducted from 1986 to 1992 using a randomized invitational design. Patients.- Forty-eight patients with moderate to severe coronary heart disease were randomized to an intensive lifestyle change group or to a usual-care control group, and 35 completed the 5-year follow-up quantitative corona social support) for 5 years. Main Outcome Measures.-Adherence to intensive lifestyle changes, changes in coronary artery percent diameter stenosis, and cardiac events. ent for the control group, 2.47 [95% confidence interval, 1.48-4.20]). many cardiac events occurred.

Keyword(s): card. lifestyle

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