Is The Amount of Loss of Trabecular Bone Dependent on Base-Line Bone Density?

Journal/Book: Z Rheumatol 1998; 57 Suppl. 1: 54 (P 37). 1998;

Abstract: 1University Clinic Balgrist Zürich Centers of Osteoporosis 2München and 3Zürich Introduction: For the tailored prophylaxis/treatment of osteoporosis we divide our patients in fast and slow losers using high precise peripheral quantitative computed tomography (Densiscan 1000 Scanco Medical Zürich). Based on the bimodal frequency distribution of the annual loss rates from the trabecular bone of the distal radius Gast losers lose > 3 % per year in the first years aAer menopause. The long term reproducibility of trabecular bone in the distal radius is 0.3 % for mixed collectives. Therefore the classification into the two groups is possible with two measurements in a time interval of only 6 months. Aim of the study: To evaluate whether the loss of trabecular bone density depends on the base line trabecular density. Patients: We divided 135 untreated normal osteopenic and osteporotic patients in 6 groups according to the trabecular bone density and the loss in the radiuslyear. The results show that the lower the trabecular bone density the higher the bone loss-probably due to augmented surface e. g. in the lowest bone density group (57 - 99 mg/ccm) we find in 75 % a fast loser state. Conclusion: Based on these data the lower the trabecular bone density is the more it is justified to use antiresorptive agents and the higher it is to use anabolic substances. ... le

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