Brain potentials in patients with music perception deficits: evidence for an early locus

Author(s): Schuppert, M., Johannes, S., Wieringa, B. M., Kohlmetz, C., Altenmuller, E.

Journal/Book: Neurosci Lett. 1998; 256: 85-8.

Abstract: Twelve patients with an acute cerebrovascular accident were assigned to a group with music perception deficits (amusia, n = 6) or a group without such deficits (n = 6) on the basis of a new test-battery for music-perception skills. Event-related brain potentials (ERPs) were recorded in an auditory classification task designed to elicit several components; the N1 as a correlate of initial auditory cortical processing, the P3a as an index of automatic attentional orienting, and the P3b as a measure for controlled stimulus evaluation. Patients with amusia showed a significant amplitude decrement for the P3a relative to controls and patients without amusia suggesting an impairment of early stimulus evaluation. P3b was reduced in both patient groups relative to control. These data show that amusia is quite common in unselected stroke patients and suggest deficits of generic rather than music- specific cognitive processes as the underlying cause.

Keyword(s): Acoustic Stimulation. Aged. Auditory Cortex/physiology. Auditory Perception/physiology. Auditory Perceptual Disorders/physiopathology. Cerebrovascular Disorders/physiopathology. Cognition. Electroencephalography. Evoked Potentials/physiology. Female. Human. Middle Age. Music. Pitch Perception/physiology. Support, Non-U.S. Gov't

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