Chemical and physiologic brain imaging in schizophrenia

Author(s): Keshavan, M. S., Pettegrew, J. W.

Journal/Book: Psychiat Clin N Amer. 1998; 21: Independence Square West, Curtis Center, Ste 300, Philadelphia, PA 19106-3399. W B Saunders Co. 93.

Abstract: Technologic advances in functional brain imaging have provided exciting and informative insights into the functional neuroanatomy and neurochemistry of schizophrenia. Using MR spectroscopy, it has been possible to examine in vivo brain metabolism and to relate observed changes to physiological processes occurring at a cellular level. Positron emission tomography and single photon emission computed tomography have revealed disturbances of cerebral blood flow and glucose metabolism in patients with schizophrenia. More recently, these tools have also proved most useful in studying the relative receptor occupancy of typical and atypical antipsychotic medications.

Note: Review Pettegrew JW, Univ Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh,PA 15213 USA

Keyword(s): MAGNETIC-RESONANCE SPECTROSCOPY; CEREBRAL BLOOD-FLOW; POSITRON-EMISSION TOMOGRAPHY; D-2 RECEPTOR OCCUPANCY; MEMBRANE PHOSPHOLIPID-METABOLISM; DORSOLATERAL PREFRONTAL CORTEX; NEWLY-DIAGNOSED SCHIZOPHRENIA; NEUROLEPTIC-NAIVE PATIENTS; D2 DOPAMINE-RECEPTORS; HIGH-ENERGY PHOSPHATE

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