Panic disorder associated with gastrointestinal disease: Review and hypotheses

Journal/Book: J Psychosom Res. 1998; 44: The Boulevard, Langford Lane, Kidlington, Oxford, England OX5 1GB. Pergamon-Elsevier Science Ltd. 91-105.

Abstract: An association between panic disorder and functional gastrointestinal disease has emerged since the introduction of reliable diagnostic criteria, first for psychiatric disorders and more recently for functional gastrointestinal disorders, At the same time, a more rigorous review of methodology of older reports linking structural gastrointestinal diseases such as peptic ulcer and inflammatory bowel disease to psychiatric illness has cast doubt on the validity of their association. In this review original articles reporting an association between panic disorder and globus, functional chest pain of presumed esophageal origin, functional dyspepsia, and irritable bowel syndrome are critically reviewed and it is concluded that panic disorder is overrepresented in noncardiac chest pain and irritable bowel syndrome. Original reports of the prevalence of panic disorder in structural gastrointestinal disease are reviewed and it is concluded that they do not support an association with panic. Hypotheses explaining the statistical link of panic disorder and functional gastrointestinal disease are discussed.

Note: Review Maunder RG, Mt Sinai Hosp, Dept Psychiat, 600 Univ Ave, Toronto, ON M5G 1X5, CANADA

Keyword(s): panic; functional gastrointestinal disorder; irritable bowel; IRRITABLE-BOWEL-SYNDROME; NORMAL CORONARY-ARTERIES; NONCARDIAC CHEST PAIN; PSYCHIATRIC-ILLNESS; ULCERATIVE-COLITIS; COLON SYNDROME; HEALTH-CARE; HYPERVENTILATION SYNDROME; BEHAVIORAL TREATMENT; MAJOR DEPRESSION

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