Functional magnetic resonance imaging of human brain activation during cue-induced cocaine craving

Author(s): Lukas, S. E., Kaufman, M. J., Weiss, R. D., Daniels, S. L., Rogers, V. W., Kukes, T. J., Renshaw, P. F.

Journal/Book: Am J Psychiatry. 1998; 155: 1400 K St NW, Washington, DC 20005. Amer Psychiatric Association. 124-126.

Abstract: Objective: Functional magnetic resonance Imaging (MRI) was used to test whether brain activation was detectable in regions previously associated with cocaine cue-induced craving. Method: Blood oxygenation level dependent (BOLD) functional activation was measured during presentation of audiovisual stimuli containing alternating intervals of drug-related and neutral scenes to six male subjects with a history of crack cocaine use and six male comparison subjects. Results: Significant activation was detected in the anterior cingulate and left dorsolateral prefrontal cortex in the cocaine-using group. In addition, a correlation between self-reported levels of craving and activation in these regions was found. Conclusions: These results suggest that Junctional MRI may be a useful tool to study the neurobiological basis of cue-induced craving.

Note: Article Maas LC, Mclean Hosp, Brain Imaging Ctr, 115 Mill St, Belmont,MA 02178 USA

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