Neural mediation of memory for time: Role of the hippocampus and medial prefrontal cortex

Journal/Book: Psychonomic Bull Rev. 1998; 5: 1710 Fortview Rd, Austin, TX 78704, USA. Psychonomic Soc Inc. 585-596.

Abstract: Within the context of the neurobiology of attribute model, memory for the temporal attribute is composed of at least three features-memory for duration, memory for succession, or temporal order, and memory for past and future time perspective within a dual-based (data and knowledge) memory system. Research aimed at testing the assumption that the hippocampus and interconnected neural circuits mediate the temporal attribute within the data-based memory system and the prefrontal cortex and interconnected neural circuits mediate the temporal attribute within the data-based memory system in animals and humans is reviewed. The research indicates that (1) memory for the duration feature of the temporal attribute is mediated by the hippocampus, but not prefrontal cortex, in bath animals and humans, (2) memory for the temporal order feature of the temporal attribute based on new information is subserved by both the hippocampus and the prefrontal cortex, but that based on prior knowledge or the ability to use prior knowledge is supported only by prefrontal cortex, and not the hippocampus, in both animals and humans, and (3) memory for the past (time perspective) feature of the temporal attribute is mediated by the hippocampus, whereas memory for the future (time perspective) feature of the temporal attribute is supported by the prefrontal cortex in both animals and humans. There is a clear parallel between animals and humans in terms of hippocampal and prefrontal cortex mediation of the temporal attribute, supporting the assumption of evolutionary continuity. There is support fdr a greater involvement of the hippocampus in comparison with the prefrontal cortex in mediating temporal attribute information within the data-based memory system. Conversely, there is support for a greater involvement of the prefrontal cortex in comparison with the hippocampus in mediating temporal attribute information within the knowledge-based memory system. Future research needs to concentrate on the development of new paradigms to measure memory for different temporal features and to uncover the critical neural circuits that subserve these temporal features.

Note: Article Kesner RP, Univ Utah, Dept Psychol, 502 SBS, Salt Lake City,UT 84112 USA

Keyword(s): FRONTAL-LOBE; PARIETAL CORTEX; RETROGRADE-AMNESIA; ENTORHINAL CORTEX; SPATIAL DISCRIMINATION; ANTEROGRADE AMNESIA; TRIPLE DISSOCIATION; DELAYED ALTERNATION; RECOGNITION MEMORY; DIRECT PROJECTION

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