First-pass versus second-pass parsing processes in a Wernicke's and a Broca's aphasic: Electrophysiological evidence for a double dissociation

Author(s): Hahne, A., vonCramon, D. Y.

Journal/Book: Brain Lang. 1998; 62: 525 B St, Ste 1900, San Diego, CA 92101-4495. Academic Press Inc Jnl-Comp Subscriptions. 311-341.

Abstract: The present paper is a first attempt to integrate the classical brain lesion behavioral impairment approach of functional neuroanatomy and the electrophysiological brain mapping approach in the domain of syntactic processing. In a group of normal age matched controls we identified three electrophysiological components previously observed in correlation with language comprehension processes: an early left anterior negativity normally seen in correlation with syntactic first-pass parsing processes (ELAN), a centroparietal negativity seen in correlation with processes of lexical-semantic integration (N400), and a late centroparietal positivity observed in correlation with secondary syntactic processes of reanalysis and repair (P600). The early left anterior negativity was absent in a patient with an extended lesion in the anterior part of the left hemisphere sparing the temporal lobe, although the late centroparietal positivity and the centroparietal N400 were present. In a patient with a left temporal-parietal lesion the early left anterior negativity was found to be present, whereas the N400 component was absent. These findings suggest that first-pass parsing and secondary processes are subserved by distinct brain systems.

Note: Article Friederici AD, Max Planck Inst Cognit Neurosci, Inselstr 22-26, D-04103 Leipzig, GERMANY

Keyword(s): EVENT-RELATED POTENTIALS; BRAIN POTENTIALS; AGRAMMATIC APHASIA; COMPREHENSION; SPEECH; SENSITIVITY; LANGUAGE; TIME; INFORMATION; ACTIVATION

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