CO2-induced panic attacks: A twin study

Author(s): Perna, G., Caldirola, D., Arancio, C., Bertani, A., DiBella, D.

Journal/Book: Am J Psychiatry. 1998; 155: 1400 K St NW, Washington, DC 20005. Amer Psychiatric Association. 1184-1188.

Abstract: Objective: The authors investigated the role of genetic factors in 35% CO2-induced panic attacks. Method: Ninety twins recruited from the general population were challenged with one-vital-capacity inhalations of 35% CO2-65% O-2 Probandwise concordance rates were calculated and rates compared for monozygotic and for dizygotic twins. Results: A significantly higher concordance was found for 35% CO2-induced panic attacks among monozygotic than dizygotic twins (55.6% Versus 12.5%). Conclusions: These results suggest a relevant role of genetic factors in 35% CO2-induced panic attacks.

Note: Article Bellodi L, Ist Sci San Raffaele, Dept Neuropsychiat Sci, Anxiety Disorders Clin & Res Unit, 29 Via Prinetti, I-20127 Milan, ITALY

Keyword(s): ALPHA(2)-ADRENERGIC RECEPTOR SENSITIVITY; CARBON-DIOXIDE HYPERSENSITIVITY; 35-PERCENT CO2; FAMILY HISTORY; CLONIDINE STIMULATION; VENTILATORY RESPONSE; ANXIETY DISORDERS; CHALLENGE TEST; DOUBLE-BLIND; HYPOTHESIS

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