High dosed therapy with Crataegus extract in patients suffering from heart failure NYHA class I and II

Author(s): Albrecht, M., Podzuweit, H., Ploch, M., Maisenbacher, J.

Abstract: 940 medical practitioners have established by documentary evidence tolerance and effectiveness of a high dosed Crataegus extract (3 x 300 mg of whitethorn [leaves and blossoms] extract) given to 3664 patients suffering from cardiac insufficiency phase I and II according to NYHA in a therapy accompanying observation. Clinical symptoms of 66.5% of the patients C/3) could be related to NYHA phase II. The high dosed Crataegus extract proved to be well tolerated by the patients: 48 of them reported from 72 undesirable events during the observation period, but only in the case of 26 patients these events could be explained by the Crataegus treatment. A possible connection to Crataegus extract was determined in 22 cases and only 5 events could really be explained by whitethorn extract. Effectiveness of whitethorn therapy has been documented at 1476 patients who were given no other medication to treat their cardiac insufficiency. A score of 9 typical Symptoms of cardiac insufficiency was established end used to diagnose changes in condition depending an whitethorn therapy after 4 and after 8 weeks of application. At the end of the observation period especially patients suffering from cardiac insufficiency phase I according to NYHA have rather had no more clinical symptoms. The average score was reduced from 6.9 points at the beginning to 1. 7 at the end of the eighth week of treatment. The average pressure-frequency-product was reduced from 117.0 mmHg/min x 100 to 105.7 mmHg/min x 100. Work tolerance at bike ergometry was increased from 93.5 to 109.7 Watt.The numerous application observating dato and experimental results about pharmacological effectiveness and protective effects an the myocard caused a discussion among pathophysiologists about a possible causal therapy with Crataegus extract, especially for patients suffering from a stimulated sympathoadrenergic system (borderline hypertension, tochycardia, arrhythmia).

Keyword(s): Crataegus

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