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Planta Med. 1997 Jun; 63(3): 220-3.

Complement-modulating properties of a kaempferol 7-O-rhamnosylsophoroside from the leaves of Morinda morindoides.

Cimanga K, de Bruyne T, Van Poel B, Ma Y, Claeys M, Pieters L, Kambu K, Tona L, Bakana P, Vanden Berghe D, Vlietinck AJ.

Department of Pharmaceutical Sciences, University of Antwerp (U.I.A.), Belgium.

A kaempferol 7-O-rhamnosylsophoroside isolated from the leaves of Morinda morindoides showed dose-dependent complement-modulating properties towards both the classical (inhibiting effect) and alternative (activating effect) pathways of the complement system. Its structure was elucidated by chemical and spectroscopic methods as kaempferol 7-O-[alpha-L-rhamnopyranosyl-(1-->6)]-[beta-D-glucopyranosyl-(1-->2)]-be ta-D-glucopyranoside, a new natural product which was named morindaoside.


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