Zhongguo Zhong Yao Za Zhi. 1997 Nov; 22(11): 667-71, 703.

[Extraction, purification and ascertainment of anti-hepatoma active principles for targeted preparation of radix Aconiti Kusnezoffii]

Huang Y, Hou S, Xie R, Zhuang Z, Wang F, Zhong N.

School of Pharmacy, West China University of Medical Sciences, Chengdu 610041.

The extraction, purification, pharmacological experiments and chemical analysis of anti-hepatoma active principles of Radix Aconiti Kusnezoffii have been studied. The results show that the medicinal material Radix Aconiti Kusnezoffii is efficacious in inhibiting hepatoma, and the active principles are mainly made up of poisonous ester alkaloids. The liver targeting delivery system will be the first choice for its anti-hepatoma preparation, and the effective component AY3a is fit for the preparation of targeted microspheres.