Changes in auditory P300 in patients with major depression and silent cerebral infarction

Author(s): Fujikawa, T., Osada, M., Yamawaki, S., Touhouda, Y.

Journal/Book: J Affective Disord. 1997; 46: PO Box 211, 1000 AE Amsterdam, Netherlands. Elsevier Science BV. 263-271.

Abstract: We examined event-related potentials in patients with senile depression and silent cerebral infarction (SCI) to clarify the features of the P300 component, P300 event-related potentials were recorded in drug-free depressed patients (N = 16) and normal controls (N = 17). All patients underwent magnetic resonance imaging and were classified as SCI-positive (N = 7) or SCI-negative (N = 9), In depressed patients, the P300 was reexamined after antidepressant treatment. Prior to treatment, P300 amplitudes in depressed patients were significantly smaller than those in normal controls (P <0.01). P300 amplitudes increased significantly in SCI-negative patients following recovery (P < 0.05), but did not change in SCI-positive patients. SCI may interrupt the treatment-related P300 amplitude increase in depressed patients.

Note: Article Yamawaki S, Hiroshima Univ, Sch Med, Dept Psychiat & Neurosci, 1-2-3 Kasumi, Hiroshima 734, JAPAN

Keyword(s): event-related potentials; P300; depression; cerebral infarction; magnetic resonance imaging; EVENT-RELATED POTENTIALS; SCHIZOPHRENIA; DISORDER; BRAIN; BIPOLAR

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