Natural killer cell activity and CSF monoamine metabolites in suicide attempters

Author(s): Hellstrom, C., Wasserman, J., Beck, O., Andersson, E., Asberg, M.

Journal/Book: Arch Suicide Res. 1997; 3: Spuiboulevard 50, PO Box 17, 3300 AA Dordrecht, Netherlands. Kluwer Academic Publ. 153-169.

Abstract: The aim of this study was to investigate markers of serotonin and immune function in suicidal patients. Cytotoxic activity of natural killer cells (NK) and CD16 lymphocytes were studied in 28 suicide attempters and 26 healthy controls, and related in patients to 5-hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid (CSF). Patients with CSF 5-HIAA below the median had significantly lower NK cell activity than other patients. CD16 cell frequency was significantly lower in patients than in controls, and patients also tended to have lower NX cell cytotoxicity than healthy controls. There were no statistically significant correlations between 4-hydroxy-3methoxyphenyl glycol (HMPG), homovanillic acid (HVA), CSF cortisol and NK cell activity. The results support the hypothesis of compromised immune function in suicidal patients with evidence of disordered serotonin function.

Note: Article Wasserman D, Karolinska Inst, Jpm, Natl & Stockholm Cty Council, Ctr Suicide Res & Prevent, Box 230, S-17177 Stockholm, SWEDEN

Keyword(s): suicide attempters; immune function; NK cell activity; CD16 cells; cerebrospinal fluid; 5-hydroxyindoleacetic acid (5-HIAA); MAJOR DEPRESSIVE DISORDER; CEREBROSPINAL-FLUID; CORTISOL CONCENTRATIONS; ALCOHOL-CONSUMPTION; SEROTONIN; BEHAVIOR; IMMUNITY; PLASMA; BRAIN; 5-HYDROXYTRYPTOPHOL

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