Searching for a predictive peripherical biological model in parasuicidal behaviour

Author(s): Bobes, J., Gonzalez, M. P., Cocana, I., GonzalezQuiros, P., Bousono, M.

Journal/Book: Eur Psychiat. 1997; 12: 141 Rue Javel, 75747 Paris Cedex 15, France. Editions Scientifiques Medicales Elsevier. 75-81.

Abstract: The aim of this study was to identify possible peripheral biological markers (both lipidic and hormonal) which can be easily used for the early detection of parasuicidal behaviour and to propose a predictive biological model of such behaviour. A case-control analytical study was undertaken at least 3 months after attempted suicide. Study was made of 128 patients who presented at the University General Hospital of Oviedo (Spain) with signs of self-intoxication. Lipidic and hormonal profiles were measured under basal conditions and comparison was made with a control group of healthy volunteer donors obtained from the Oviedo General Hospital blood bank. A discriminant analysis was later made with the aim of establishing a predictive biological model. This included the following variables: cholesterol, HDL-C, LDL-C and cortisol. Sensitivity and specificity were 62.5% and 65.6%, respectively. Replication and improvement of this model, through other prospective studies, could lead to the use of serum cholesterol and cortisol levels as inexpensive and readily available markers of suicide risk.

Note: Article Saiz PA, Univ Oviedo, Sch Med, Dept Psychiat, Julian Claveria 6, E-33006 Oviedo, SPAIN

Keyword(s): parasuicidal behaviour; biological markers; cholesterol; cortisol; LOW SERUM-CHOLESTEROL; HONOLULU-HEART-PROGRAM; SUICIDAL-BEHAVIOR; ADRENOCORTICAL FUNCTION; PSYCHIATRIC-INPATIENTS; PRIMARY PREVENTION; BLOOD CHOLESTEROL; SOCIAL-BEHAVIOR; TERM MORTALITY; DEATH

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