5-HT1A receptor binding sites in post-mortem brain samples from depressed suicides and controls

Author(s): DePaermentier, F., Cheetham, S. C., Crompton, M. R., Katona, C. L. E., Horton, R. W.

Journal/Book: J Affective Disord. 1997; 42: PO Box 211, 1000 AE Amsterdam, Netherlands. Elsevier Science BV. 199-207.

Abstract: 5-HT1A receptor binding sites were measured, by saturation binding with [H-3]8-OH-DPAT, in frontal and occipital cortex, hippocampus and amygdala obtained at post-mortem examination from suicide victims with a firm retrospective diagnosis of depression, and matched controls. The number of 5-HT1A binding sites did not differ significantly between suicides and controls, either in the total sample or when the suicides were divided on the basis of violence of death or recent antidepressant treatment.

Note: Article Lowther S, St George Hosp, Sch Med, Dept Pharmacol & Clin Pharmacol, London SW17 0RE, ENGLAND

Keyword(s): suicide; depression; 5-HT1A receptor binding sites; post-mortem brain tissue; antidepressant drugs; cerebral cortex; hippocampus; amygdala; MAJOR DEPRESSION; RAT-BRAIN; ELECTROCONVULSIVE SHOCK; INTRAVENOUS TRYPTOPHAN; MONOAMINE METABOLITES; UNIPOLAR DEPRESSION; PLASMA PROLACTIN; SEROTONIN; RESPONSES; VICTIMS

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