Schizophrenia, psychosis, and the basal ganglia

Author(s): Kerwin, R. W.

Journal/Book: Psychiat Clin N Amer. 1997; 20: Independence Square West, Curtis Center, Ste 300, Philadelphia, PA 19106-3399. W B Saunders Co. 897.

Abstract: Schizophrenia is one of the most common and perhaps the most disabling of mental disorders, for which effective forms of treatment have not yet been established definitively. The findings reviewed in this article strongly suggest that basal ganglia abnormalities are involved in the pathophysiology of psychotic syndromes in general, and schizophrenia in particular.

Note: Article Busatto GF, Hc Fmusp, Ctr Med Nucl, Travessa Rua Ovidio Pires Campos S-N, BR-05403010 Sao Paulo, BRAZIL

Keyword(s): POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; CAUDATE NUCLEI VOLUMES; D2 DOPAMINE-RECEPTORS; COMPUTED-TOMOGRAPHY; AUDITORY HALLUCINATIONS; SPONTANEOUS DYSKINESIA; NEUROLEPTIC TREATMENT; ANTIPSYCHOTIC-DRUGS; AFFECTIVE-DISORDER

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