Extracts from VISCUM and CRATAEGUS are cytotoxic against larynx cancer cells

Journal/Book: Z-Naturforsch 52 (1-2), 42-44. 1997;

Abstract: The effects of hexanoic extracts of *Viscum* cruciatum Sieber parasiticon Crataegus monogyna Jacq. (I), Crataegus monogyna Jacq. parasitizedwith *Viscum* cruciatum Sieber (II), and Crataegus monogyna Jacq.non-parasitized (III), and of a triterpenes enriched fractions isolatedfrom I, II and III (CFI, CFII, CFIII respectively), on the growth ofHEp-2 cells have been evaluated. All the samples demonstratedsignificant cytotoxic activity against cultured HEp-2 cells, and all ofthem showed a stronger in vitro activity than 6-mercaptopurine solutionused as a positive control. With the hexanoic extracts I, II and IIIalmost similar activity was obtained, but the hexanoic extract I showedcomparably better results. Almost complete inhibition was observed withtriterpenes-enriched fractions CFI, CFII and CFIII, at the dose 6micrograms/ml, after 72 h of treatment. The most intense response wasobtained with the triterpenes-enriched fraction CFIII (from Crataegusmonogyna non-parasitized), where the inhibition was 93%, but thefraction CFI and CFII showed similar inhibition (92% and 83%). Author.

Keyword(s): ANTINEOPLASTIC-AGENTS-PHYTOGENIC/IP (isolation & purification), TO(toxicity)

Zurück | Weiter