Zhonghua Jie He He Hu Xi Za Zhi. 1996 Feb; 19(1): 26-8.

[Using ligustrazini and angelica sinensis treat the bleomycin-induced pulmonary fibrosis in rats]

Dai L, Hou J, Cai H.

Drum Tower Hospital, Nanjing.

OBJECTIVE: To seek a kind of Chinese traditional medicine to treat the bleomycin-induced pulmonary fibrosis. METHODS: SD rats with bleomycin A(s) induced pulmonary fibrosis, were divided into 4 groups. Normal control group (10 rats), untreated model group (35 rats), ligustrazini group (10 rats), Angelica sinensis group (10 rats). Both ligustrazini and angelica sinensis were given intraperitoneally by injection daily for 28 days. Then all rats were put to death and took out the lungs for examination. Using histopathological examination and image processing computer assisted to evaluate the result of treatments. RESULTS: Ligustrazini could obviously reduced alveolitis and fibrosis and Angelica sinensis had the similar but lesser result. CONCLUSION: Ligustrazini and angelica sinensis have successful result of treatment for pulmonary fibrosis.