J Ethnopharmacol. 1996 Oct; 54(1): 41-6.

Effect of a herbomineral preparation D-400 in streptozotocin-induced diabetic rats.

Mitra SK, Gopumadhavan S, Muralidhar TS, Anturlikar SD, Sujatha MB.

Research and Development Centre, Himalaya Drug Co., Makali, Bangalore, India.

This study was undertaken to investigate the effect of D-400, a herbomineral formulation on blood sugar and other biochemical parameters in streptozotocin-induced diabetic rats. There was significant reduction in blood urea nitrogen, serum creatinine and serum uric acid levels in the D-400-treated group and considerable lowering of AUC in oral glucose tolerance test (OGTT). The D-400-treated group showed significant lowering of triglycerides and HDL cholesterol. There was a rise in hepatic glycogen level close to normal after D-400 treatment. In the pancreas of diabetic rats, D-400 therapy showed significant increase in islet number and beta cell count and appeared to bring about blood sugar homoeostasis by increasing insulin secretion and repair/regeneration of endocrine pancreas.