Glia, hippocampal learning and the formation of neocortical representations

Author(s): Bluff, K.

Journal/Book: Brain Cognition. 1996; 32: 525 B St, Ste 1900, San Diego, CA 92101-4495. Academic Press Inc Jnl-Comp Subscriptions. 226-229.

Abstract: A modified approach to hippocampal learning can be derived by extending consideration to glial cells and, in particular, astrocytes. Mechanisms are outlined that provide the hippocampus with a slow learning mechanism based on astrocyte-astrocyte associations and a fast learning mechanism involving synaptic modifications in neurons. Lnteraction between them provides a basis for tackling the shortcomings of current accounts of LTP. A mechanism is described for the consolidation of neocortical representations as a result of the functioning of the hippocampal system. Performance capabilities of the type of hippocampal system described are being explored through development of a computational model.

Note: Article Wallace JG, Swinburne Univ Technol, POB 218, Hawthorn, Vic 3122, AUSTRALIA

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