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January 2022

Suicidality, circadian activity rhythms and platelet serotonergic measures in patients with recurrent suicidal behaviour

Author(s): Kerkhof, G. A., Beld, E., Hengeveld, M. W., Vankempen, G. M. J.

Journal/Book: Acta Psychiatr Scand. 1996; 93: 35 Norre Sogade, PO Box 2148, DK-1016 Copenhagen, Denmark. Munksgaard Int Publ Ltd. 27-34.

Abstract: The circadian activity rhythm was assessed over a one-week period using a wrist-worn activity monitor in 59 patients with a history of recurrent suicide attempts. In 40 of these patients a second recording was made 6 months later. Platelet serotonin (5-HT) and monoamine oxidase-B activity (MAO) were measured. Suicidal ideation, borderline personality disorder and impulsiveness were associated with the absence of a clear 24-hour periodicity in motor activity. Depressive mood and hopelessness were associated with a less regular bed-in time and a lower daytime activity. Platelet 5-HT as well as MAO correlated negatively with the amplitude of the circadian activity rhythm. Our results support the suggested link between suicidality, altered circadian activity and serotonergic function.

Note: Article RJ Verkes, Univ Leiden Hosp, Dept Psychiat, B1-P, POB 9600, 2300 RC Leiden, Netherlands

Keyword(s): circadian activity; suicidal behaviour; platelet; serotonin; monoamine oxidase; borderline personality disorder; impulsiveness; 5-HT2 RECEPTOR-BINDING; SLOW-WAVE SLEEP; BLOOD-PLATELETS; WHOLE-BLOOD; CEREBROSPINAL-FLUID; DEPRESSED-PATIENTS; MONOAMINE-OXIDASE; MOTOR-ACTIVITY; DISORDERS; INPATIENTS

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