Effects of ORG-2766 on brain event-related potentials of autistic children

Author(s): Kemner, C., Buitelaar, J. K., Vanree, J. M., Vanbeijsterveld, C. E. M., Vanengeland, H.

Journal/Book: Psychiatry Res. 1996; 63: Customer Relations Manager, Bay 15, Shannon Industrial, Estate Co, Clare, Ireland. Elsevier Sci Ireland Ltd. 33-45.

Abstract: A double-blind, placebo-controlled study examined the effects of 6 weeks of treatment with the adrenocorticotropin(4-9) analogue ORG-2766 (40 mg/day) on brain event-related potentials (ERPs) of autistic children, In visual and auditory oddball paradigms (with task and nontask conditions), standard (80%), target (10%), and unexpected novel stimuli (10%) were presented, ORG-2766 (a) increased the occipital P-3 component of the ERP to visual targets, (b) decreased the occipital P-3 component of the ERP to auditory targets, (c) did not affect visual and auditory parietal target P-3 components, and (d) also did not affect the A/P-cz/300 to auditory novel stimuli. In addition, ORG-2766 treatment increased the N-1 component of the ERP to task-irrelevant auditory stimuli.

Note: Article H Vanengeland, Univ Utrecht, Rudolf Magnus Inst Neurosci, Dept Child & Adolescent Psychiat, Heidelberglaan 100, NL-3584 Cx Utrecht, Netherlands

Keyword(s): child psychiatry; adrenocorticotropin(4-9); attention; electrophysiology; occipital lobe; ADRENOCORTICOTROPIC HORMONE 4-9; DEVELOPMENTAL LANGUAGE DISORDER; CORTICAL EVOKED-POTENTIALS; REACTION-TIME PARADIGM; AUDITORY INFORMATION; CHILDHOOD AUTISM; FREQUENCY-DOMAIN; ANALOG ORG-2766; ACTH; STIMULUS

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