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May 2022

Predicting rate of cognitive decline in probable Alzheimer's disease

Author(s): Carson, K. A., Brookmeyer, R., Kawas, C., Brandt, J.

Journal/Book: Brain Cognition. 1996; 31: 525B Street, Suite 1900, San Diego, CA 92101-4495. Academic Press Inc Jnl-Comp Subscriptions. 133-147.

Abstract: Recent attempts to identify predictors of rate of decline in Alzheimer's disease (AD) have been extremely variable in choice of outcome variables, predictor variables tested, timing of assessments, and statistical approaches. In this study, a random effects regression model was applied to seek predictors of decline on the Mini-Mental State Exam in 132 patients with probable AD reassessed every 6 months for up to 7.5 years. Potential predictor variables at baseline were of three types: patient characteristics, clinical variables, and cognitive performances, The final multivariate analysis indicated that the following characteristics predicted more rapid cognitive decline: more education, history of dementia in a first degree relative, non-right handedness, better performances on Boston Naming Test, Gollin Incomplete Figures Test, and Benton Visual Retention Test-Delay, and worse performances on Responsive Naming Test, WAIS-R Block Design, and Benton Visual Retention Test-Copy. (%O Article J Brandt, Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 600 N Wolfe St, Meyer 218, Baltimore, MD 21287 USA

Keyword(s): MILD SENILE DEMENTIA; EXTRAPYRAMIDAL SIGNS; LONGITUDINAL DATA; PROGRESSION; EDUCATION; IMPAIRMENT; ONSET; FEATURES; PATTERN; AGE


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