Meta-analysis of P300 normative aging studies

Journal/Book: Psychophysiology. 1996; 33: 1010 Vermont Ave NW, Suite 1100, Washington, DC 20005. Soc Psychophysiol Res. 334-353.

Abstract: The theoretical and empirical backgrounds for the utility of the P300 event-related potential (ERP) as a measure of cognitive aging are summarized. P300 latency data from 32 different normative aging studies are then reviewed and assessed with meta-analytic procedures. Evaluation of moderator variables indicates that sample characteristics, stimulus factors, and task conditions contribute significantly to the ''normal'' change in peak latency that occurs with aging. These findings are critiqued in the context of previous reports, and implications are outlined for future applications of ERPs to normative aging. It is concluded that P300 latency can provide useful information about cognitive aging but that specific variables must be considered to obtain more precise results.

Note: Review J Polich, Scripps Clin & Res Inst, Dept Neuropharmacol TPC10, 10666 N Torrey Pines Rd, La Jolla, CA 92037 USA

Keyword(s): P300; normative aging; meta-analysis; ERP; review; EVENT-RELATED POTENTIALS; HUMAN HIPPOCAMPAL-FORMATION; AUDITORY EVOKED-POTENTIALS; INTER-STIMULUS INTERVAL; TEMPORAL-LOBE LESIONS; ELDERLY SUBJECTS; PSYCHOPHYSIOLOGICAL ANALYSIS; SOMATOSENSORY STIMULI; LATENCY VARIABILITY; HUNTINGTONS-DISEASE

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