Auditory event-related potentials before and after treatment with nasal continuous positive airway pressure in sleep apnea syndrome

Author(s): Paquereau, J., Meurice, J. C., Chavagnat, J. J., Pinonvignaud, M. L., Vandel, B., Recard, D., Ingrand, P., Gil, R.

Journal/Book: Eur J Neurology. 1996; 3: 2-6 Boundary Row, London, England SE1 8NH. Rapid Science Publishers. 29-35.

Abstract: Auditory event-related potentials (ERP), multiple sleep latency tests, mini-mental state exam, and depression tests were studied in 15 patients with obstructive sleep apnea syndrome (OSA). The P3 wave latency of ERP was significantly increased compared with 15 age-matched control subjects. After 4 weeks and after 1 year of treatment of OSA by nasal continuous positive airway pressure (CPAP), there was no significant improvement in the abnormalities of ERP. These observed changes in ERP were not correlated with excessive daytime sleepiness, depression, nocturnal hypoxemia, and sleep fragmentation. The cause of increased P3 latency has not been elucidated, but a chronic cerebral insult was suspected.

Note: Article JP Neau, Chu La Miletrie, Neurol Clin, Hop Jean Bernard, F-86021 Poitiers 05, France

Keyword(s): obstructive sleep apnea syndrome; auditory evoked-related potentials; continuous positive airway pressure; PROGRESSIVE SUPRANUCLEAR PALSY; NEUROPSYCHOLOGICAL DEFICITS; DYSFUNCTION; NARCOLEPSY; IMPAIRMENT; DEPRESSION; DEMENTIA; LATENCY; P300; CPAP

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