Clinical applications of biological aspects of suicide (Reprinted from Preventive strategies on suicide: State of the art)

Journal/Book: Arch Suicide Res. 1996; 2: Spuiboulevard 50, PO Box 17, 3300 AA Dordrecht, Netherlands. Kluwer Academic Publ. 55-74.

Abstract: New information continues to emerge at a bewildering pace in biological science. This has resulted in a challenge to the clinician, both to remain abreast of the information and to determine its usefulness. This challenge is as true in suicide as in other aspects of modem psychiatry. This paper attempts to outline the information and to address the clinical applications of biological aspects of suicide. The most consistent candidate for potential clinical use as an indicator of suicide risk has been serotonin and its metabolite 5-hydroxyindoleactic acid. However, despite these developments it is concluded that the clinical application of these ideas would be premature.

Note: Reprint Motto JA, 424 Occidental Ave, San Mateo,CA 94402 USA

Keyword(s): suicide; biological aspects; serotonin; 5-hydroxyindoleacetic acid; clinical applications; TRITIATED IMIPRAMINE BINDING; CEREBROSPINAL-FLUID; 5-HYDROXYINDOLEACETIC ACID; FRONTAL-CORTEX; NORADRENERGIC FUNCTION; MONOAMINE METABOLITES; BIOCHEMICAL MARKERS; DEPRESSED-PATIENTS; AMINE METABOLITES; MAJOR DEPRESSION

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