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January 2022

Genetic basis for resistance to polytropic murine leukemia viruses in the wild mouse species Mus castaneus

Author(s): Kozak, C. A.

Journal/Book: J Virol. 1996; 70: 830-3.

Abstract: Cultured cells derived from the wild mouse species Mus castaneus were found to be uniquely resistant to exogenous infection by polytropic mink cell focus-forming (MCF) murine leukemia viruses (MuLVs). This MCF MuLV resistance is inherited as a genetically recessive trait in the progeny of F1 crosses between M. castaneus and MCF MuLV-susceptible laboratory mice. Examination of the progeny of backcrosses demonstrated that susceptibility is inherited as a single gene which maps to chromosome 1. The map location of this gene places it at or near the locus Rmc1, the gene encoding the receptor for MCF/xenotropic MuLVs, suggesting that resistance is mediated by the M. castaneus allele of this receptor.

Keyword(s): Mink Cell Focus-Inducing Viruses [physiology]; Muridae [genetics]

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