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January 2022

Study design in clinical research: Sample size estimation and power analysis

Journal/Book: Can J Anaesth. 1996; 43: 1 Eglinton Ave East, Suite 208, Toronto on M4P 3A1, Canada. Canadian Anaesthetists Soc Inc. 184-191.

Abstract: The purpose of this review is to describe the statistical methods available to determine sample size and power analysis in clinical trials. The information was obtained from standard textbooks and personal experience. Equations are provided for the calculations and suggestions are made for the use of power tables. It is concluded that sample size calculations and power analysis can be performed with the information provided and that the validity of clinical investigation would be improved by greater use of such analyses.

Note: Article J Lerman, Hosp Sick Children, Dept Anaesthesia, 555 Univ Ave, Toronto, on M5G 1X8, Canada

Keyword(s): statistics, sample size calculation, power analysis


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