The development of in vivo tracer methods to obtain new information about human disease: A study of the hallucinating brain

Author(s): Silbersweig, D. A., Stern, E., Schnorr, L., Seaward, J., Clark, J. C., Lammertsma, A. A., Grootoonik, S.

Journal/Book: Eur J Nucl Med. 1996; 23: 175 Fifth Ave, New York, NY 10010. Springer Verlag. 332-335.

Abstract: An outline is provided of the development of methodological strategies to address the question of focal cerebral activation during hallucinations in schizophrenic patients. In so doing, the innovation and diligence required to tailor in vivo tracer procedures to specific clinical research issues are highlighted. Attention is drawn to the complexity of methodological advances and the way in which they are based upon close scientific and technical collaboration between clinical scientists, and non-clinical scientists and research support staff.

Note: Article T Jones, Hammersmith Hosp, Royal Postgrad Med Sch, MRC, Cyclotron Unit, Clin Sci Ctr, du Cane Rd, London W12 0HS, England

Keyword(s): schizophrenia; in vivo tracer studies; methodological evolution; hallucinations; RETRACTABLE SEPTA

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