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May 2022

The use of hallucinogens in the treatment of addiction

Journal/Book: Addict Res. 1996; 4: C/O Stbs Ltd, PO Box 90, Reading, Berks, England RG1 8JL. Harwood Acad Publ GmbH. 177-189.

Abstract: Research into treating drug dependence with hallucinogens, although promising, ended with questions still unanswered because of varying, in some cases skeptical, methodology and insufficient adherence to a double-blind, placebo-controlled design. Interest is again emerging, especially with the recent patenting in the United States of ibogaine for its apparent anti-craving properties. A review of the literature shows that these properties may be present across the entire family of hallucinogens. Potential efficacy may be tied to their agonism and antagonism at specific serotonin receptor sites. After the administration of a hallucinogen, there is a positive ''afterglow'' lasting weeks to months which might be extended through repeated dosing. Ibogaine and LSD both have lengthy periods of action, making their application unwieldy. However, tryptamines, such as N,N-Dimethyltryptamine (DMT), are so short-acting that they could easily be administered in an office setting. With numerous hallucinogens yet to be tested, a hallucinogen might well be discovered with superior anti-craving properties and nondeleterious side-effect profile.

Note: Article JH Halpern, Brigham & Womens Hosp, Div Psychiat, 4TH Fl, 221 Longwood Ave, Boston, MA 02115 USA

Keyword(s): LSD; ibogaine; N,N-dimethyltryptamine (DMT); therapeutic Use; drug dependence; serotonin; PHENETHYLAMINE HALLUCINOGENS; INVIVO MICRODIALYSIS; ETHANOL INTAKE; LYSERGIC-ACID; DOSE-RESPONSE; D-AMPHETAMINE; IBOGAINE; RATS; DOPAMINE; DRUGS


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