Measures of prefrontal dysfunction after closed head injury

Author(s): Covall, S., Mcgrath, N., Oscarberman, M.

Journal/Book: Brain Cognition. 1996; 30: 525B Street, Suite 1900, San Diego, CA 92101-4495. Academic Press Inc Jnl-Comp Subscriptions. 194-204.

Abstract: Tasks sensitive to frontal lobe dysfunction (delayed response, delayed alternation, object alternation, and Wisconsin Card Sort) were administered to 20 patients with post-acute closed-head injury (CHI). Time since injury varied (6 to 280 months; mean, 48 months), as did length of coma (2 hr to 120 days; mean, 38 days). Compared to normal controls, CHI patients showed no deficits on delayed response tasks, but were impaired on delayed alternation, object alternation, and the Wisconsin Card Sort Test. Analyses of the performance profiles of the CHI patients suggested that they may have difficulty in establishing set (a consequence of damage to the orbitofrontal system). (%O Article DA Gansler, Vet Affairs Med Ctr, Psychol Serv 116B, 150 S Huntington Ave, Boston, MA 02130 USA

Keyword(s): DIFFUSE AXONAL INJURY; COMPARATIVE NEUROPSYCHOLOGY; KORSAKOFFS SYNDROME; DELAYED ALTERNATION; PERFORMANCE; ATROPHY

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