Circadian rhythm and the per ACNGGN repeat in the mole rat, Spalax ehrenbergi

Author(s): Ritte, U., Nevo, E.

Journal/Book: Behav Genet. 1996; 26: 233 Spring St, New York, NY 10013. Plenum Publ Corp. 177-184.

Abstract: Individual variability in circadian locomotor activity has recently been discovered in the blind mole rat, Spalax ehrenbergi. An interesting association was found between different circadian activity types and two DNA fragments, 5.6 and 5.9 kb long, that contain the ACNGGN repeat sequence, homologous to a part of the period gene of Drosophila. Nine of 12 arrythmic animals showed the 5.6-kb band, while 13 of 17 circadian rhythmic animals had the 5.9-kb band. This repeat exists also in the brain RNA of the mole rat, apparently in higher quantities during the sleeping phase, suggesting that an unusual protein(s), composed of a poly-Thr-Gly segment, affects its circadian rhythm.

Note: Article R Benshlomo, Univ Leicester, Dept Genet, Univ Rd, Leicester LE1 7RH, Leics, England

Keyword(s): subterranean mole rats; Spalax ehrenbergi; circadian rhythm; Drosophila period gene; ACNGGN repeat sequence; restriction fragment length polymorphism; DROSOPHILA CLOCK GENE; SUPRACHIASMATIC NUCLEUS; VISUAL-SYSTEM; MESSENGER-RNA; PERIOD GENE; PRODUCT; SEQUENCE; ISRAEL; SHARES; BRAIN

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