Electrophysiologic mechanisms of perpetuation of atrial fibrillation

Author(s): Konings, K., Kirchhof, C. J. H. J., Wijffels, M.

Journal/Book: Am J Cardiol. 1996; 77: 249 West 17 Street, New York, NY 10011. Cahners Publ Co. A10-A23.

Abstract: The presence of an excitable gap during atrial fibrillation (AF), although short and variable, may be of potential importance for the development of alternative techniques for termination of AF by rapid pacing. Also the notion that perpetuation of AF may be partly dependent on macroreentry around the natural atrial orifices, may provide a new therapeutic option for the permanent cure of AF by interrupting the anatomical circular pathways in the atria by radiofrequency ablation. in our opinion the rapidly growing understanding of the electrophysiologic mechanisms of AF certainly warrants some optimism about the possibility of cure of AF in the near future without causing too much discomfort and without carrying an unacceptable risk.

Note: Article MA Allessie, Univ Limburg, Cardiovasc Res Inst, Dept Physiol, POB 616, 6200 MD Maastricht, Netherlands

Keyword(s): SINUS RHYTHM; ACUTE CONVERSION; CARDIAC-MUSCLE; ANISOTROPIC PROPAGATION; FLECAINIDE ACETATE; REFRACTORY PERIOD; NATURAL-HISTORY; CIRCUS MOVEMENT; CONSCIOUS DOGS; FLUTTER

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