Oxidativer Streß und Antioxidantienmangel - Risikofaktoren für koronare Herzerkrankungen?
Abstract: Epidemiological studies show evidence, that antioxidants protect against coronary heart disease. The assumption that the oxidative damage of lipoproteins by free radicals plays an important role in the development of atherosclerosis is of increasing significance. Oxidation of low-density-lipoprotein (LDL) causes the formation of foam cells and atherosclerotic lesions. This process could be prevented by the antioxidants vitamin E and ß-carotene. Recent reports from clinical and prospective studies support the protective role of the antioxidants and show, that there is an inverse correlation between antioxidant plasma levels and coronary heart disease and implicate that a low antioxidant plasma level could enhance the risk for the development of coronary heart disease.
Keyword(s): Koronare Herzerkrankung