Rilmenidine prevents epinephrine-induced arrhythmias in halothane-anesthetized dogs

Author(s): Kamibayashi, T., Hayashi, Y., Takada, K., Yamatodani, A., Yoshiya, I.

Journal/Book: J Cardiovasc Pharmacol. 1995; 26: 227 East Washington Sq, Philadelphia, PA 19106. Raven Press. S40-S43.

Abstract: Stimulation of central alpha(2)-adrenoceptors has been known to prevent epinephrine-induced arrhythmias in halothane-anesthetized dogs. Because recent studies suggested that several physiological processes that were traditionally attributed to activation of alpha(2)-adrenoceptors, such as hypotensive action, are mediated through imidazoline receptors (IRs), it may be likely that IRs are involved in the antiarrhythmic action. We investigated the hypotensive effect of rilmenidine, a selective IR agonist (1, 3, and 10 mu g/kg i.v.), and the antiarrhythmic effects of the drug on epinephrine-induced arrhythmias during halothane anesthesia in dogs. Although the hypotensive effect of rilmenidine was not remarkable in the dose range we tested, rilmenidine increased the arrhythmogenic threshold for epinephrine in a dose-dependent manner during halothane anesthesia, achieving statistical significance at 10 mu g/kg, the highest dose we examined. These results suggest that rilmenidine prevents epinephrine-induced arrhythmias during halothane anesthesia and that this effect is more potent than its hypotensive action.

Note: Article T Mammoto, Osaka Univ, Fac Med, Dept Anesthesiol, 2-2 Yamadaoka, Suita, Osaka 565, Japan

Keyword(s): epinephrine induced arrhythmias; halothane; imidazoline receptors; rilmenidine; IMIDAZOLINE-PREFERRING RECEPTORS; NUCLEUS-RETICULARIS LATERALIS; CATECHOLAMINES; SELECTIVITY; CLONIDINE; PRESSURE; BRAIN

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