Effect of intratympanically administered gentamicin on hearing and tinnitus in Meniere's disease

Author(s): Pyykko, I., Ishizaki, H., Aalto, H.

Journal/Book: Acta Oto-Laryngol. 1995; PO Box 2959 Toyen, Journal Division, Customer Service, N-0608 Oslo, Norway. Scandinavian University Press. 184-185.

Abstract: We have examined the effect of intratympanic gentamicin on hearing and tinnitus in 69 patients with intractable Meniere's disease. Tinnitus was scored from 1 to 4 depending on its severity. The mean pure tone audiometry level before treatment was 57.5 dB and 1 year after treatment 63.5 dB. Five subjects became deaf in the treated ear, and in 13 subjects hearing loss was > 10 dB and in 21 subjects 0-10 dB. In 25 subjects significant improvement (> 10 dB) was gained, and in 5 patients hearing remained unchanged. The older subjects developed greater post-treatment hearing loss than the younger patients. Tinnitus was significantly reduced after treatment with gentamicin. A total of 66 patients had tinnitus before treatment and tinnitus relief was rated as good. Four percent of the subjects had no tinnitus, 30% had slight tinnitus, 27% moderate tinnitus, 18% severe, and 8% handicapping tinnitus.

Note: Article I Pyykko, Karolinska Hosp, Dept Otolaryngol, S-17176 Stockholm, Sweden

Keyword(s): Meniere; gentamicin; tinnitus

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