Benign prostatic hyperplasia specific health status measures in clinical research: How much change in the American Urological Association symptom index and the benign prostatic hyperplasia impact index is perceptible to patients?

Author(s): Williford, W. O., Chang, Y. C., Machi, M., Jones, K. M., Walkercorkery, E., Lepor, H.

Journal/Book: J Urol. 1995; 154: 351 West Camden St, Baltimore, MD 21201-2436. Williams & Wilkins. 1770-1774.

Abstract: Purpose: We assessed the relationship between changes in scores for the American Urological Association (AUA) symptom index and benign prostatic hyperplasia (BPH) impact index with patient global ratings of improvement in a large Veterans Affairs trial comparing different pharmacological therapies for BPH. Materials and Methods: The primary analyses compared absolute score changes from baseline with global ratings of improvement-at 13 weeks for 1,218 men. Results: Subjects who rated themselves as being slightly improved had a mean decrease in AUA symptom index and BPH impact index scores of 3.1 and 0.4 points, respectively. However, the baseline scores strongly influenced this relationship. Conclusions: These data provide guidance for investigators using the AUA symptom index and BPH impact index as outcome measures.

Note: Article MJ Barry, Massachusetts Gen Hosp, Ctr Med Practices Evaluat, Boston, MA 02114 USA

Keyword(s): prostatic hypertrophy; questionnaires; outcome assessment (health care)

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