Influence of the galactoside - specific lectin from VISCUM ALBUM and its subunits on cell aggregation and selected intracellular parameters of rat thymocytes

Journal/Book: Planta Medica 61 (2), 130-133. 1995;

Abstract: Galactose-specific lectin from Viscum album (VAA) was shown to inducethe aggregation of rat thymocytes, to increase the intracellularCa(2+)-availability, and to enhance the menadione-dependent release ofH2O2 from cells in a carbohydrate- and dose-dependent manner. Thisactivity was mediated by the carbohydrate-binding B-subunit, whereas thetoxic A-subunit failed to display aggregating activity or to affect theintracellular Ca2+. However, incubation of cells in its presencedecreased the release of H2O2. These data extend the knowledge of theimmunomodulatory potency of VAA, especially its carbohydrate-binding Bchain. Author.

Keyword(s): ANIMAL

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